Objectively characterizing Huntington’s disease using a novel upper limb dexterity test
نویسندگان
چکیده
Abstract Background The Clinch Token Transfer Test (C3t) is a bi-manual coin transfer task that incorporates cognitive tasks to add complexity. This study explored the concurrent and convergent validity of C3t as simple, objective assessment impairment reflective disease severity in Huntington’s, not reliant on clinical expertise for administration. Methods One-hundred-and-five participants presenting with pre-manifest ( n = 16) or manifest (TFC-Stage-1 39; TFC-Stage-2 43; TFC-Stage-3 7) Huntington’s completed Unified Disease Rating Scale at baseline. Of these, thirty-three were followed up after 12 months. Regression was used estimate baseline individual composite scores (including cognitive, motor, functional ability) using scores. Correlations between assessed Spearman’s R visually inspected relation scatterplots. Effect size over months provided an indication longitudinal behaviour measures. Results Baseline predicted within 9–13% accuracy, being associated Changes small $$\Omega$$ ? ? 0.15) mirrored change Conclusion demonstrates promise easy administer, outcome measure capable predicting offers viable solution support remote monitoring. It may also offer utility screening tool recruitment trials given preliminary indications association prognostic index normed disease.
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ژورنال
عنوان ژورنال: Journal of Neurology
سال: 2021
ISSN: ['0340-5354', '1432-1459']
DOI: https://doi.org/10.1007/s00415-020-10375-8